Es gibt noch viel darüber zu lernen, wie Doxorubicin, ein 50 Jahre altes Chemotherapeutikum, seine besorgniserregendsten Nebenwirkungen verursacht. Obwohl dieses Medikament viele Leben gerettet hat, verursacht es manchmal Herzschäden, die das Herz versteifen und bei einigen Patienten das Risiko eines zukünftigen Herzversagens erhöhen. Um solche Komplikationen besser zu verstehen und möglicherweise kontrollieren zu können, haben Forscher der Tufts University School of Medicine und der Tufts Graduate School of Biomedical Sciences die Immunzellen isoliert, die überaktiv werden, wenn Patienten Doxorubicin einnehmen. Die Ergebnisse des Teams erscheinen am 17. Juli in der Fachzeitschrift Nature Cardiovascular Research .Doxorubicin ist für Onkologen die erste Wahl als erste Verteidigungslinie gegen verschiedene Krebsarten, da es die Zellteilung und damit das Tumorwachstum verlangsamen oder stoppen kann. Es wurde nachgewiesen, dass das Medikament eine entzündungsfördernde Reaktion im Herzen auslösen kann, es gibt jedoch keine Intervention, die dies allgemein… 

Xueqing Hu , Ujjwol Khatri , Tao Shen , and Jie Wu, at University of Oklahoma Health Sciences Center, USA, provides a comprehensive review of the role of the RET (REarranged during Transfection) receptor tyrosine kinase in cancer development and the advancements in RET-targeted cancer therapies. RET, a transmembrane receptor tyrosine kinase, plays a crucial role in various cellular processes, including embryogenesis and cell development. However, when aberrantly activated due to mutations or chromosomal rearrangements, RET can act as an oncogenic driver in many cancers, notably non-small cell lung cancer (NSCLC). The review discusses the early trials of multikinase tyrosine kinase inhibitors (TKIs) that were initially used to treat RET-altered thyroid cancer and NSCLC, with limited success. The development of more potent and selective RET TKIs, such as pralsetinib and selpercatinib, marked a significant advancement in RET-targeted therapy. These drugs… 

Space storms could soon be forecasted with greater accuracy than ever before thanks to a big leap forward in our understanding of exactly when a violent solar eruption may hit Earth. Scientists say it is now possible to predict the precise speed a coronal mass ejection (CME) is travelling at and when it will smash into our planet – even before it has fully erupted from the Sun. CMEs are bursts of gas and magnetic fields spewed into space from the solar atmosphere. They can cause geomagnetic storms that have the potential to wreak havoc with terrestrial technology in Earth’s orbit and on its surface, which is why experts across the globe are striving to improve space weather forecasts. Advancements such as this one could make a huge difference in helping to protect infrastructure that is vital to our everyday…