A new DOI-anchored white paper published on February 7, 2026, proposes a structured, hierarchical framework of terminology to advance research on chronic, microbiome-mediated inflammation and systemic regulatory states. The document appears in Bioengineering & Biotechnology and is openly accessible under a CC BY 4.0 license.
Authored by Reyed M. Reyed, Associate Professor at SRTA-CITY (City of Scientific Research and Technological Applications, Egypt), the paper introduces key constructs designed to provide mechanistic clarity, improve experimental design, support predictive modeling, and facilitate translational interventions in polybiome and precision medicine studies.
Core proposed terms include:
- Panflemmosis
- Dysgutome
- Colobiota
- EuColobiota
- Micrometabionics
- COMO
The framework adopts a cross-kingdom perspective, integrating microbial, fungal, and metabolic networks in the context of systemic pathologies. It aims to create a scalable, citable lexicon that researchers can build upon for future work in microbiome science, immunometabolism, oncology, precision nutrition, and AI-driven systems medicine.
Reyed, whose research focuses on microbiome–cancer interactions, host–microbe dynamics, drug–microbiome modulation, and multi-omics integration, positions the terminology within his broader Polybiome Systems Medicine framework. This integrative model links oncology, microbiome ecology, nutrition, environmental exposures, and artificial intelligence into a unified translational architecture.
The white paper is available at DOI: 10.5281/zenodo.18511678.
The announcement was posted on the Research Communities by Springer Nature platform in the Biomedical Engineering and Bioengineering community.
