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Medigene Presents Favorable Safety Profile of TCR-T Cells with Costimulatory Switch Protein at AACR Annual Meeting 2024

Planegg/Martinsried, April 8, 2024. Medigene AG (Medigene or the “Company”, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, today presents superior recombinant T cell receptor (rTCR) engineered T cell functionality as well as a favorable safety profile when rTCR-T cells are armored and enhanced with the PD1-41BB costimulatory switch protein (CSP) at the American Association for Cancer Research (AACR) Annual Meeting 2024 taking place April 5-10, 2024, in San Diego, USA. Medigene Presents Favorable Safety Profile of TCR-T Cells with Costimulatory Switch Protein at AACR Annual Meeting 2024

Forscher töten Hirntumorzellen mit Plasma ab

Wissenschaftlern und Medizinern der Westsächsischen Hochschule Zwickau (WHZ), des Heinrich-Braun-Klinikums Zwickau (HBK) und des Universitätsklinikums Magdeburg ist es gelungen, Hirntumorzellen durch die Behandlung mit physikalischem Plasma abzutöten. Durch das Verfahren soll es möglich werden, Hirnhauttumore restlos zu entfernen. Hirntumore stellen sowohl Patienten als auch die behandelnden Ärzte vor große Herausforderungen. Durch ihr verdrängendes oder invasives Wachstum können sie erhebliche neurologische Beschwerden nach sich ziehen und unter Umständen auch das Leben bedrohen. Die komplette Entfernung eines Hirntumors ist leider nicht immer, ohne die Gesundheit des Patienten zu gefährden, möglich. Verbliebene Tumorreste erhöhen aber die Wahrscheinlichkeit eines erneuten Tumorwachstums. Genau an diesem Punkt setzen Prof. Dr. Maik Fröhlich von der Westsächsischen Hochschule Zwickau (WHZ) und die Mediziner PD Dr. Michael Luchtmann und Dirar Aldabek vom Heinrich-Braun-Klinikum Zwickau (HBK) sowie Prof. Dr. Christian Mawrin und Peter John vom Institut für Neuropathologie des Universitätsklinikums… 

mRNA药物旨在降低血液中的脂质

根据布莱根妇女医院(麻省总医院联合医疗系统创始成员)研究人员领导的一项安慰剂对照、双盲研究,一种实验性疗法可能会进一步降低血液中的甘油三酯。研究结果在2024年美国心脏病学会科学会议及博览会(American College of Cardiology’s 2024 Annual Scientific Session & Expo)上公布,并同时发表在《新英格兰医学杂志》(New England Journal of Medicine)上。在这项研究中,154名接受了中度至重度高甘油三酯血症脂质治疗的成年人被随机分配接受50毫克Olezarsen、80毫克Olezarsen或安慰剂。Olezarsen是一种反义寡核苷酸,通过靶向APOC3基因的mRNA来抑制APOC3,该基因与甘油三酯水平升高有关。该皮下注射药物每四周给药一次,持续一年。与安慰剂相比,50毫克剂量的Olezarsen将甘油三酯水平降低了49%,而… 

前列腺癌筛查(PSA、激肽释放酶组套和MRI)

In this preliminary descriptive report from an ongoing randomized clinical trial, one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected among those randomized to be invited to undergo a single prostate cancer screening intervention compared with those not invited to undergo screening. These preliminary findings from a single round of screening should be interpreted cautiously, pending results of the study’s primary mortality outcome. Authors: Anssi Auvinen, M.D., Ph.D., of Tampere University in Tampere, Finland, is the corresponding author. https://jamanetwork.com/journals/jama/fullarticle/2817323?guestAccessKey=0ec76eb2-a05b-4ae3-b31c-7a662e979189&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040624

Oral vaccine for UTI is potential alternative to antibiotics

Recurrent Urinary Tract Infections (UTIs) can be prevented for up to nine years in more than half of people given an oral spray-based vaccine and is a potential alternative to antibiotic treatments, finds research. Initial results from the first long-term follow-up study of the safety and effectiveness of the MV140 vaccine for recurrent UTIs are presented this weekend at the European Association of Urology (EAU) Congress in Paris. They show that in both men and women with recurrent UTIs, 54% of study participants remained UTI-free for nine years after the vaccine, with no notable side effects reported. Full results of the study are expected to be published by the end of 2024.

EHRA 2024:  New evidence links passive smoking with dangerous heart rhythm disorder

Exposure to secondhand smoke – even at small amounts – is linked with greater risk of a serious heart rhythm disorder, according to research presented at EHRA 2024, a scientific congress of the European Society of Cardiology (ESC). The likelihood of atrial fibrillation increased as the duration of passive smoking lengthened. “The dangers of secondhand smoke were significant regardless of whether individuals were at home, outdoors, or at work, indicating that exposure universally elevates the risk of atrial fibrillation,” said study author Dr. Kyung-Yeon Lee of Seoul National University Hospital, Seoul, Republic of Korea. “We should all make every effort to avoid spending time in smoky environments. The findings should also drive policymakers to further curb smoking in public areas and support smoking cessation programmes to improve public health.” https://esc365.escardio.org/EHRA-Congress/sessions/10100

Experimental drug could further reduce lipids in the blood in high-risk patients

An experimental treatment could further lower triglycerides in the blood, according to a placebo-controlled and double-blind trial led by researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system. Results were presented at the 2024 American College of Cardiology’s Annual Scientific Session & Expo and simultaneously published in the New England Journal of Medicine. The trial randomized 154 adults on lipid-lowering therapy with moderate or severe hypertriglyceridemia to receive either 50mg olezarsen, 80mg olezarsen or placebo. Olezarsen is an antisense oligonucleotide that inhibits APOC3, a gene associated with higher levels of triglycerides, by targeting its mRNA. The subcutaneous medication was administered every four weeks, for a period of a year. Olezarsen reduced triglyceride levels by 49% at the 50mg dose and 53% at the 80mg dose, compared with placebo. The experimental drug also reduced… 


Antengene Presents Four Preclinical Posters at AACR 2024

Antengene announced the presentation of four preclinical posters at the 2024 American Association for Cancer Research Annual Meeting (AACR 2024), taking place from April 5th to April 10th at the San Diego Convention Center in San Diego, California, the United States. The posters showcased four of Antengene’s high-potential emerging programs, including ATG-042, tracking to a H1 2025 IND filing; ATG-022, in Phase II dose expansion studies in China and Australia; AnTenGagerTM platform, Antengene’s proprietary T-cell engager (TCE) platform; and ATG-102, which could be the first IND candidate from AnTenGagerTM platform.

Antengene在AACR 2024上展示四项临床前海报

Antengene announced the presentation of four preclinical posters at the 2024 American Association for Cancer Research Annual Meeting (AACR 2024), taking place from April 5th to April 10th at the San Diego Convention Center in San Diego, California, the United States. The posters showcased four of Antengene’s high-potential emerging programs, including ATG-042, tracking to a H1 2025 IND filing; ATG-022, in Phase II dose expansion studies in China and Australia; AnTenGagerTM platform, Antengene’s proprietary T-cell engager (TCE) platform; and ATG-102, which could be the first IND candidate from AnTenGagerTM platform.