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Rare non-small cell lung cancer with brain metastases responds to amivantamab monotherapy

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A team led by first author Jinah Kim of the University of Vermont Medical Center and corresponding author Young Kwang Chae of Feinberg School of Medicine reports on a clinical case in which a patient with advanced non-small cell lung cancer (NSCLC) and rare EGFR mutations responded remarkably well to amivantamab after other treatments had failed. The patient experienced complete resolution of brain and cerebrospinal fluid metastases. This suggests that amivantamab could be a viable option for patients with unusual genetic profiles and limited treatment options. Lung cancer remains one of the leading causes of cancer-related deaths worldwide. Patients with NSCLC and rare mutations in the EGFR gene often have limited treatment options and poor prognoses, especially if the disease has spread to the brain or cerebrospinal fluid. This case involved a 67-year-old man diagnosed with NSCLC who had two rare EGFR mutations – G719A… 

Virtual reality training tool combats contamination of portable medical devices

Infection control researchers at Mass General Brigham have developed a virtual reality (VR) training tool to educate clinicians on core infection control concepts, including the cleaning and disinfection of portable medical devices, to prevent the spread of infections in healthcare settings. They successfully piloted the VR training tool across seven U.S. facilities and hope such training can improve staff competency and patient safety. The work was published in “Infection Control & Hospital Epidemiology.” “Devices like blood pressure cuffs, glucometers, and portable imaging devices are ubiquitous in healthcare, and study after study has shown that healthcare settings fail to clean and disinfect them, increasing the risk of healthcare-associated infections,” said senior author Erica S. Shenoy, MD, PhD, chief of infection control at Mass General Brigham. “We know that patient risk decreases when basic infection control measures are correctly…” 

World's first 2D computer without silicon developed

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Silicon is the king of semiconductor technology, which underpins smartphones, computers, electric vehicles, and more. But according to a research team from Pennsylvania State University, its crown may soon crumble. As the world's first, they used two-dimensional (2D) materials, which, unlike silicon, are only one atom thick and retain their properties at this scale, to develop a computer that can perform simple operations. The development, published today (June 11) in Nature, represents a major step toward realizing thinner, faster, and more energy-efficient electronics, according to the researchers. They developed a CMOS (Complementary Metal-Oxide Semiconductor) computer – the technology at the heart of almost all modern electronic devices – without silicon. Instead, they used two different 2D materials to develop the two types of transistors needed to control the flow of electrical current in CMOS computers: molybdenum disulfide for n-type transistors and tungsten diselenide for p-type transistors. The team utilized the... 

Nocturia: How often is normal?

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Villingen-Schwenningen, June 11, 2025 – Those who are repeatedly woken up by a full bladder at night know the frustration: Sleep is disturbed, recovery suffers, and the risk of falling increases, especially for older people. But how often is nighttime urination actually normal, and when should one take action? A report from the Pharmaceutical Journal sheds light on the causes and solutions for the phenomenon, medically known as nocturia. Up to twice per night is normal According to Professor Dr. Daniela Schultz-Lampel, Director of the Continence Center Southwest at Klinikum Schwarzwald-Baar, it is considered normal to visit the toilet up to twice per night. "However, if you regularly have to get up more often, you should have the causes medically clarified," advises the urologist. Nocturia, the medical term for nighttime urinary urgency, can not only disrupt sleep but also indicate health problems. Diverse causes for nocturia The reasons for frequent nighttime urination are... 

Chemical company Dow cuts apprenticeship positions in Schkopau and Böhlen: 26 young people affected

Schkopau/Böhlen, June 11, 2025 – The US chemical company Dow has announced that it will completely cancel the 2025/2026 training year at its East German locations in Schkopau (Saxony-Anhalt) and Böhlen (Saxony). This means that 26 young people, who were supposed to start their training on September 1, will lose their apprenticeships at short notice. The decision has caused horror and incomprehension, especially in light of the already tense situation in the chemical industry. Cost-cutting measures and uncertain future Dow justifies the cancellation of apprenticeships with economic cost-saving pressures and unclear future prospects. The company is under pressure as high energy prices and the general crisis in the energy-intensive chemical sector are burdening production sites. In addition, Dow is currently examining the possible shutdown or closure of individual plants in Schkopau and Böhlen, which further exacerbates the uncertainty. "The decision not to hire new trainees is part of our measures to reduce costs," explained a company spokesperson. The affected young people are now facing the challenge,… 

Military parade in Washington: Pompous celebration and controversial defense line

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Washington, D.C., June 11, 2025 – This coming Saturday, June 14, 2025, the US capital will be the scene of a massive military parade to celebrate the 250th anniversary of the US Army and President Donald Trump's 79th birthday. With approximately 6,600 soldiers, 150 military vehicles – including historical Sherman tanks from World War II as well as modern Abrams and Bradley tanks – and 50 aircraft, including Apache and Black Hawk helicopters, the event will be a martial spectacle. But behind the festive occasion, a controversy is brewing: Some of the tanks are to remain in the city after the parade as a defense line against possible protests. A historic march with a political undertone The parade, which will lead from the Pentagon in Arlington across the Memorial Bridge to the National Mall, is intended to be "the largest and most beautiful military parade in the history of the USA," according to Secretary of Defense Pete Hegseth. In addition to modern weapon systems such as Himars rocket launchers and M109… 

Novavax’s COVID-19-Influenza Combination and Stand-alone Influenza Vaccine Candidates Showed Robust Immune Responses in Initial Cohort of a Phase 3 Trial

Novavax, Inc. (Nasdaq: NVAX) today announced results of the initial cohort of its COVID-19-Influenza Combination (CIC) and stand-alone trivalent hemagglutinin nanoparticle seasonal influenza (tNIV) Phase 3 trial that showed both the CIC and flu vaccine candidates induced immune responses similar to licensed comparators Nuvaxovid® and Fluzone HD, respectively. This cohort was designed to provide descriptive data on three flu strains (H1N1, H3N2, B) and SARS-CoV-2 (COVID-19) to inform a future registrational Phase 3 program. Both stand-alone flu and CIC vaccine candidates induced robust immune responses to the vaccine strains (2.4-5.7-fold over baseline). Both vaccine candidates were well tolerated and saw reactogenicity comparable to authorized comparators. Nearly all (>98%) solicited adverse events were mild or moderate in severity. This descriptive trial was designed to evaluate the safety and immunogenicity of the CIC and stand-alone flu vaccine candidates compared to Nuvaxovid and… 

Clinical Observational Study: A Systematic Investigation of Allegations Regarding Cocaine Use by Chancellor Friedrich Merz

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IntroductionIn May 2025, a viral video triggered a global controversy, showing German Chancellor Friedrich Merz (CDU), French President Emmanuel Macron, and British Prime Minister Keir Starmer during a train journey to Kyiv. The video, viewed millions of times on platforms like X and Telegram, led to speculation about alleged cocaine use by the politicians. Pro-Russian actors, including Maria Zakharova, spokesperson for the Russian Ministry of Foreign Affairs, claimed Merz and Macron had consumed cocaine, citing a white object (allegedly a cocaine bag) and an elongated object (allegedly a snorting spoon). This observational study systematically analyzes the allegations, examines the visual evidence, assesses clinical plausibility, and contextualizes the disinformation campaign within social scientific and medical methodologies. The aim is to demonstrate the baselessness of the claims and illuminate the mechanisms of targeted propaganda. MethodologyThis retrospective observational study is based on a multimodal analysis integrating primary and secondary sources. Primary sources include… 

New antibodies offer broad protection against SARS coronaviruses

Ghent, June 11, 2025 – A research team from the VIB-UGent Center for Medical Biotechnology has discovered a class of small antibodies that offer strong protection against a broad spectrum of SARS coronaviruses, including SARS-CoV-1 and various SARS-CoV-2 variants. The findings, published in Nature Communications, show that these antibodies block a highly conserved region on the virus's spike protein, thereby preventing infections. The discovery promises new approaches for broadly effective antiviral therapies that could also withstand future virus variants. The antibodies, known as nanobodies, were derived from llamas and target the S2 subunit of the spike protein, which is crucial for cell infection and stable across coronaviruses. Unlike conventional therapies that often target the mutation-prone receptor-binding domain, these nanobodies lock onto the spike protein like a molecular clamp, preventing the conformational change necessary for infection. Lab tests showed that the antibodies, even at low doses… 

Vitamin B12 Deficiency: Every Fourth Person Over 65 Affected

Berlin, June 11, 2025 – A quarter of people in Germany over the age of 65 suffer from a deficiency of vitamin B12, a vital nutrient for blood formation and nerve function. Such a deficiency can have serious consequences, including cognitive impairment, lack of motivation, or depression, warns the pharmacy magazine Senioren Ratgeber. The deficiency often arises from impaired absorption of the vitamin in the gut, which is common in older people. Furthermore, certain medications such as omeprazole, metformin, or antibiotics increase the risk of deficiency. Vegans and vegetarians are particularly at risk, as vitamin B12 is primarily found in animal products such as meat, fish, eggs, and dairy products. Treatments include dietary supplements and higher-dose medications. The latter are reimbursed by health insurance companies upon medical prescription and proven medical necessity, while dietary supplements must be paid for out-of-pocket. For prevention, a balanced diet with foods such as quark, yogurt, liver…  is recommended.