The Power of Myokines – Muscles as Endocrine Organs
In recent years, medical research has opened a fascinating chapter on the role of myokines, a group of peptides and proteins produced and released by skeletal muscles. These molecules, often referred to as "muscle hormones," have far-reaching physiological effects and are revolutionizing our understanding of musculature as an endocrine organ. Myokines not only mediate local effects in muscle tissue but also influence systemic processes ranging from metabolic regulation to immune modulation. The discovery of myokines dates back to studies showing that physical activity offers far-reaching health benefits beyond mere muscle strengthening. A key molecule is Interleukin-6 (IL-6), which is released in large quantities during muscle contraction. Unlike in inflammatory contexts, where IL-6 has pro-inflammatory effects, muscular IL-6 has anti-inflammatory properties and promotes glucose uptake and fat metabolism. This dual role underscores the context-dependent function of myokines. In addition to IL-6 ...

