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Neue Methode verbessert Ligandendesign für chemische Reaktionen

Eine neue Methode optimiert das Design und die Wirksamkeit von Liganden, die bei chemischen Reaktionen in der Katalyse und Arzneimittelabgabe verwendet werden. Forscher an der Universität Hokkaido in Japan haben eine Technik namens Virtual Ligand-Assisted Optimization (VLAO) entwickelt, um das Design und die Wirksamkeit von Liganden zu verbessern. Liganden sind wichtige Moleküle, die bei chemischen Reaktionen, insbesondere bei der Katalyse, verwendet werden. Die in der Zeitschrift ACS Catalysis veröffentlichte Studie beschreibt den neuen Ansatz im Detail, der den komplexen und zeitaufwändigen Prozess des Liganden-Engineerings rationalisiert. Liganden binden bei chemischen Reaktionen an zentrale Metallatome und beeinflussen, wie diese Metalle mit anderen Substanzen interagieren. Eigenschaften wie Größe, Form und Ladung können die Reaktionsgeschwindigkeit und die Art der erzeugten Produkte stark beeinflussen. Liganden werden in vielen Bereichen eingesetzt, von der industriellen Fertigung bis hin zu gezielten medizinischen Therapien. Die Optimierung von Liganden für… 

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Neue Wirkstoffziele für Alzheimer identifiziert

Ein Forscherteam der Washington University School of Medicine in St. Louis hat mithilfe von Liquor cerebrospinalis (CSF) lebender Patienten erstmals krankheitsbedingte Proteine und Gene miteinander in Verbindung gebracht und so spezifische zelluläre Signalwege identifiziert, die für die Entstehung und das Fortschreiten der Alzheimer-Krankheit verantwortlich sind. Da diese Proteine aus der CSF gewonnen wurden, sind sie ein guter Indikator für die Aktivität im Gehirn, und einige von ihnen könnten potenzielle Ziele für Therapien sein. Die Ergebnisse sind in Nature Genetics verfügbar. „Die Verwendung der Zerebrospinalflüssigkeit von Patienten stellt für derartige Studien einen Fortschritt dar und ist möglicherweise der beste Weg, um relevante Proben zu gewinnen, die dabei helfen, die Konstellation der Proteinaktivität (das sogenannte Proteom) abzubilden“, sagt  Dr. Carlos Cruchaga, Professor für Psychiatrie an der Barbara Burton and Reuben Morriss III-Universität und Leiter des  Zentrums für NeuroGenomik und Informatik an der… 

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USA: Devastating obesity epidemic

In the last three decades, there has been a frightening increase in obesity cases in the USA; since 1990, the number of adult men and women (aged 25 and over) and older female and male adolescents (aged 15 to 24) has at least doubled. In 2021, the number of overweight and obese people will rise to over 208 million – a trend that is likely to continue in the coming decades without significant reforms, according to a new comprehensive analysis by the Global Burden of Disease Study Collaborator Network, published in The Lancet. Several US states have already reached particularly high rates of overweight and obesity: More than half (52%) of older male adolescents (aged 15–24) in Texas and almost two-thirds (63%) of older female adolescents in Mississippi were living with overweight or obesity in 2021. This is also the case for…

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Remote Telemedicine Tool Found Highly Accurate in Diagnosing Melanoma

Collecting images of suspicious-looking skin growths and sending them off-site for specialists to analyze is as accurate in identifying skin cancers as having a dermatologist examine them in person, a new study shows. According to the study authors, the findings add to evidence that such technology could help to reliably address diagnostic and treatment disparities for lower-income populations with limited access to dermatologists. It may also help dermatologists quickly catch cases of melanoma, a serious form of skin cancer that kills more than 8,000 Americans a year. Their new system, which the researchers call SpotCheck, enables skin cancer specialists to remotely examine skin lesions using an established technique called dermoscopy, in which experts use a camera connected to a specialized magnifying lens to peer beneath the skin’s surface. While previous research has explored telemedicine options for speeding diagnoses of melanoma… 

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Sonnenschutz führt zu Vitamin D Mangel

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Vitamin D, ein lebenswichtiger Nährstoff, wird auf natürliche Weise durch Sonneneinstrahlung und bestimmte Nahrungsmittel produziert. Übermäßige Maßnahmen zur Vorbeugung von Sonnenbrand führen jedoch zu einem schwerwiegenden Vitamin-D-Mangel, insbesondere bei jungen Frauen in Japan. Da Vitamin-D-Mangel auch mit schwangerschaftsbedingtem Bluthochdruck und niedrigem Geburtsgewicht bei Kindern in Zusammenhang steht, ist es wichtig, Hochrisikopatienten schnell zu identifizieren und entsprechende Gesundheitsberatung zu bieten. Die derzeit etablierte Methode zur Messung des Vitamin-D-Spiegels im Serum ist jedoch teuer und invasiv; daher besteht Bedarf an der Entwicklung einfacherer Instrumente zur Risikobewertung. So führte eine Forschungsgruppe unter der Leitung von Professor Akiko Kuwabara an der Graduate School of Human Life and Ecology der Osaka Metropolitan University eine Querschnittsstudie mit 583 japanischen Frauen im Alter zwischen 18 und 40 Jahren durch, die an einer Universität mit Schwerpunkt Ernährung studierten. Die Umfragepunkte waren Alter, Wohnort, Zeitpunkt der Blutentnahme, aktuelle Krankengeschichte,… 

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First-ever FDA approval for gene therapy directly administered to the brain

PTC Therapeutics, Inc. (NASDAQ: PTCT) announced the U.S. Food and Drug Administration (FDA) accelerated approval of its gene therapy for the treatment of AADC deficiency, the first-ever gene therapy approved in the United States that is directly administered to the brain. The gene therapy, which will be marketed in the United States with the brand name KEBILIDI™ (eladocagene exuparvovec-tneq), is indicated for the treatment of children and adults with AADC deficiency, including the full spectrum of disease severity. Launch preparations are well underway, with centers of excellence already identified and surgeons trained in the procedure to deliver the gene therapy. AADC deficiency is a highly morbid and life-shortening rare genetic disorder that results in the inability to synthesize dopamine, a neurotransmitter essential for motor function. KEBILIDI is a gene replacement therapy that is directly administered to the putamen of the… 

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Implantica submits FDA PMA application Clinical Module 2 for RefluxStop™ for U.S. market approval

Implantica AG (publ.), a medtech company at the forefront of introducing advanced technology into the body, including the unique device RefluxStop™ for the treatment of acid reflux, a treatment field with 1 billion sufferers, announces the submission of the second clinical module of the Premarket Approval (PMA) application to the US FDA for RefluxStop™ along with responses to the FDA’s findings from the first module. The second module submitted earlier this week for the RefluxStop™ PMA is the most crucial module of the three-module process for FDA approval. The outcome of our clinical study submitted to FDA shows fantastic positive results, which has echoed around the surgical community, fueling a vibrating interest in RefluxStop among surgeons and GIs all around the world and especially in the U.S. Together with Module 2, responses to the FDA’s findings from Module 1 were …

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Implantica submits FDA PMA application Clinical Module 2 for RefluxStop™ for U.S. market approval

Suvoda Awarded US Patent for its eCOA Software Architecture

Suvoda, a global clinical trial technology company specializing in complex studies in therapeutic areas like oncology, central nervous system (CNS), and rare diseases, announced the receipt of a patent from the US Patent Office for the Suvoda Questionnaire Definition Language (SQDL), part of the software architecture of its eCOA (electronic Clinical Outcome Assessment) product. The patent demonstrates the power of Suvoda eCOA: expedited questionnaire creation, translation, localization, and deployment so clinical trial sponsors can launch their studies more efficiently. While eCOA is traditionally a bottleneck in clinical trial implementation, Suvoda eCOA and its SQDL tool enable sponsors to deliver high quality questionnaires in a matter of hours, instead of days. 

FDA authorizes first AI-driven MRI solution for safer Alzheimer’s treatment

On November 7th 2024, the U.S. Food and Drug Administration (FDA) granted icometrix clearance for icobrain aria, the first and only AI software approved for detecting, measuring and grading amyloid-related imaging abnormalities (ARIA), a potentially harmful side effect of new amyloid-targeting therapies. A large study, needed for FDA clearance, demonstrated that the use of icobrain aria significantly increases the accuracy of ARIA assessments by radiologists and hence allows for safer use of new amyloid-beta targeting therapies for Alzheimer’s disease patients. The first disease-modifying therapies for Alzheimer’s disease have come to the market over the previous years – providing hope to the millions affected by Alzheimer’s disease. These therapies have been linked to the development of specific brain abnormalities known as Amyloid-Related Imaging Abnormalities (ARIA), which, although rare, can lead to neurological complications.Regular brain MRI scans are needed to assess ARIA,… 

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IB Lab FROG: AI-powered foot angle measurements for orthopedic diagnostics

ImageBiopsy Lab, a leading provider of AI solutions for musculoskeletal imaging, has launched IB Lab FROG. The AI module, which is CE certified according to the standards of the European Medical Device Regulation (MDR), offers a comprehensive suite of automated measurements on X-ray images. It was developed for radiological and orthopedic assessment of the foot and provides clinicians with precise, standardized data […] ImageBiopsy Lab has released IB Lab FROG: AI-powered foot angle measurements for orthopedic diagnostics