In Asien wächst die Sorge vor einem Anstieg der Insolvenzen in den kommenden Monaten. Das geht aus der aktuellen Ausgabe 2024 des Atradius Payment Practices Barometer Asia hervor. Beeinträchtigt wird dadurch insbesondere der B2B-Handel auf Kredit. Für die Hälfte der von Atradius in Asien befragten Unternehmen hat sich das steigende Insolvenzrisiko als eine der Hauptsorgen… Asiens Unternehmen erwarten Anstieg der Insolvenzen
Eli Lilly and Company (NYSE: LLY) announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorization for donanemab, an injection for intravenous infusion every four weeks to treat mild cognitive impairment and mild dementia due to Alzheimer’s disease in eligible adults in Great Britain. Eligible patients are limited to apolipoprotein E ?4 (ApoE ?4) heterozygotes or non-carriers, which is a requirement for the class of currently approved amyloid-targeting therapies in Great Britain. Donanemab is the only amyloid plaque-targeting therapy with evidence to support stopping therapy when amyloid plaques are removed. Great Britain is the third major market to approve donanemab, marketed as Kisunla. Amyloid is a protein produced naturally in the body that can clump together to create amyloid plaques. The excessive buildup of amyloid plaques in the brain may lead to memory and thinking…
Some patients apparently have to pay for treatments at the doctor's office that are actually covered by health insurance. This has emerged from a consumer call by the Federation of German Consumer Organisations (VZBV), which received around 300 reports between February and September and which the Funke Mediengruppe newspapers reported on. The analysis shows that some treatments are unjustifiably classified as individual health services (IGeL) […] Consumer association criticizes incorrect billing of statutory health insurance services
Researchers from Children’s Hospital of Philadelphia (CHOP) demonstrated how rapid testing of cytokine levels can help distinguish different diseases with similar symptom profiles. Nearly 30% of clinicians changed how they managed disease in children after receiving cytokine level information, showing the potential for this testing to impact clinical practice. The findings were recently published in the Journal of Allergy and Clinical Immunology. During the COVID-19 pandemic, doctors began diagnosing patients with multisystem inflammatory syndrome in children (MIS-C), a condition that occurs weeks after infection and results from inflammation throughout the body. However, the initial symptoms – such as high fever and changes in blood pressure – are very similar to those of an acute, severe COVID-19 infection, so doctors needed to be able to distinguish between the two conditions, since each one requires a very different course of treatment. Distinguishing…
Immunic, Inc. (Nasdaq: IMUX), a biotechnology company developing a clinical pipeline of orally administered, small molecule therapies for chronic inflammatory and autoimmune diseases, today announced a positive outcome of the non-binding, interim futility analysis of its phase 3 ENSURE program, investigating lead asset, nuclear receptor related 1 (Nurr1) activator, vidofludimus calcium (IMU-838), for the treatment of relapsing multiple sclerosis (RMS). Based on the outcome of the interim futility analysis, an unblinded Independent Data Monitoring Committee (IDMC) has recommended that the trials are not futile and should continue as planned. The ongoing ENSURE program comprises two identical multicenter, randomized, double-blind phase 3 trials designed to evaluate the efficacy, safety and tolerability of vidofludimus calcium versus placebo in RMS patients. Each of the trials, titled ENSURE-1 and ENSURE-2, is expected to enroll approximately 1,050 adult patients with active RMS at more than…
Mpox, formerly known as monkeypox, remains a relevant health topic in Germany. Although case numbers have significantly decreased since the 2022 outbreak, sporadic infections still occur. In 2024, 86 Mpox cases have been reported in Germany so far, 33 of them in Berlin alone[9]. On October 18, 2024, the new Mpox variant Clade Ib was detected for the first time in Germany[1][2]. This variant, which has been spreading in Africa for some time, is considered potentially more contagious and dangerous than previous variants[7]. The affected patient had been infected abroad. Despite this individual case, the Robert Koch Institute (RKI) continues to assess the risk to the general population as low[2]. An approved vaccine is available in Germany for the prevention of Mpox. The Standing Committee on Vaccination (STIKO) recommends vaccination for specific risk groups, including men who have sex with men and frequently change partners, as well as…
Heart failure, medically known as cardiac insufficiency, is a widespread condition that is often recognized late. Many affected individuals ignore the first signs such as shortness of breath, fatigue, or swollen legs and attribute them to age or other ailments. However, these symptoms in particular can be precursors to heart failure, in which the heart can no longer pump sufficient blood and oxygen throughout [...] Heart failure: Often unrecognized, but treatable
A difficult-to-describe nano-object called a magnetic skyrmion could one day lead to new microelectronic devices that can do much more – for example, store huge amounts of data – while consuming much less power. But in order to ever reliably use skyrmions in computing devices, including quantum computers, researchers need to understand them even better. Peter Fischer, a lead researcher at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), led a project to create 3D X-ray images of skyrmions that can characterize or measure the spin orientation throughout the entire object. "Our results provide the foundation for nanometer technology for spintronic devices," said Fischer. The work was recently published in Science Advances. Magnetic skyrmions can be thought of as spinning magnetic vortices, explains David Raftrey, a student researcher in Fischer’s team who was the lead author of this study. In the center, the magnetic spin points up,…
Myasthenia gravis (MG) is a chronic autoimmune disease in which antibodies block communication between nerves and muscles, leading to skeletal muscle weakness. It can cause double vision, difficulty swallowing, and occasional severe breathing problems, among other symptoms. Many autoimmune diseases like MG, as well as a number of other human diseases, result from the inability to regulate the activity of IgG antibodies – these diseases are collectively referred to as IgG-mediated pathologies. In a paper published this month in Cell, researchers at Emory University have discovered a family of enzymes that reduce IgG-mediated pathologies in diseases like MG. The findings, conducted in mouse models, show that a particular enzyme (an endoglycosidase called CU43) was particularly effective in treating diseases caused by overactive antibodies. The newly discovered enzyme was used to treat a range of different IgG-mediated pathologies in mice and proved…
Die Aujeszkysche Krankheit (AK) stellt eine ernsthafte Bedrohung für Hunde und Katzen dar und kommt in Wildschweinpopulationen vor. Diese Viruserkrankung, die primär Schweine befällt, verläuft bei Hunden und Katzen immer tödlich[1][2]. Der Erreger, das Suide Herpesvirus 1, auch als Pseudorabiesvirus bekannt, ist in Deutschland vor allem in Wildschweinpopulationen verbreitet[7]. Die Übertragung auf Hunde und Katzen […] Aujeszkysche Krankheit: Kein Impfstoff für Hunde und Katzen
