Xueqing Hu , Ujjwol Khatri , Tao Shen , and Jie Wu, at University of Oklahoma Health Sciences Center, USA, provides a comprehensive review of the role of the RET (REarranged during Transfection) receptor tyrosine kinase in cancer development and the advancements in RET-targeted cancer therapies. RET, a transmembrane receptor tyrosine kinase, plays a crucial role in various cellular processes, including embryogenesis and cell development. However, when aberrantly activated due to mutations or chromosomal rearrangements, RET can act as an oncogenic driver in many cancers, notably non-small cell lung cancer (NSCLC). The review discusses the early trials of multikinase tyrosine kinase inhibitors (TKIs) that were initially used to treat RET-altered thyroid cancer and NSCLC, with limited success. The development of more potent and selective RET TKIs, such as pralsetinib and selpercatinib, marked a significant advancement in RET-targeted therapy. These drugs… 

Space storms could soon be forecasted with greater accuracy than ever before thanks to a big leap forward in our understanding of exactly when a violent solar eruption may hit Earth. Scientists say it is now possible to predict the precise speed a coronal mass ejection (CME) is travelling at and when it will smash into our planet – even before it has fully erupted from the Sun. CMEs are bursts of gas and magnetic fields spewed into space from the solar atmosphere. They can cause geomagnetic storms that have the potential to wreak havoc with terrestrial technology in Earth’s orbit and on its surface, which is why experts across the globe are striving to improve space weather forecasts. Advancements such as this one could make a huge difference in helping to protect infrastructure that is vital to our everyday… 

In 10 years, solid-state batteries made from rock silicates will be an environmentally friendly, more efficient and safer alternative to the lithium-ion batteries we use today. Researcher at DTU have patented a new superionic material based on potassium silicate – a mineral that can be extracted from ordinary rocks. It is the battery in your electric car that determines how far you can drive on one charge and how quickly you can re-charge. However, the lithium-ion battery, the most widely used electric car battery today, has its limitations— in terms of capacity, safety and also availability. Because lithium is an expensive, environmentally harmful material and the scarcity of the relatively rare metal can hinder the green transition of car transport. As more and more people switch to electric cars, we need to develop a new generation of lithium-free batteries, which…