آفاق جديدة في مراقبة مسببات الأمراض من خلال تقنيات التسلسل
A pre-proof article published in aBIOTECH on November 29, 2025, highlights significant advancements in sequencing-based pathogen surveillance, offering hope for improved global health, food security, and ecological resilience. Authored by a team from the Agricultural Genomics Institute at Shenzhen, the study addresses the growing threat of infectious diseases in livestock, plants, and humans, emphasizing the limitations of traditional diagnostic methods. The research points out that conventional approaches, such as morphological observation and biochemical identification, are often slow and lack the sensitivity needed for timely detection. In contrast, high-throughput sequencing technologies, including multiplex PCR-based targeted sequencing, have emerged as powerful tools. These methods provide enhanced sensitivity, specificity, and cost-efficiency, making them ideal for detecting a wide range of pathogens. However, challenges like primer design issues, including dimerization and bias, remain hurdles to their effectiveness. The study explores innovative strategies to overcome…
