In a recent study published in the Journal of Biomedical Optics, researchers from the Indian Institute of Technology Indore unveiled a groundbreaking advancement—a compact and cost-effective PA sensing instrument designed specifically for biomedical tissue diagnosis. This proof-of-concept study employs low-cost diode laser. It represents a crucial step towards bridging the gap between laboratory research and clinical applications.
The newly developed instrument integrates multiple laser diodes within a compact casing, alongside a custom-built pulsed current supply unit. This setup ensures efficient PA excitation, generating precise 25 nanosecond pulses at a frequency of 20 kHz. Subsequent data analysis involved calculating frequency spectra to quantitatively assess tissue properties.
The results revealed distinct spectral patterns corresponding to different tissue types. For instance, fibrocystic breast disease exhibited a dominant frequency peak around 1.60 MHz, indicative of increased tissue density due to heightened glandular and stromal elements. In contrast, normal breast tissue showcased a lower peak frequency of 0.26 MHz, reflecting its fibrofatty composition.
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-29/issue-01/017002/Development-of-a-cost-effective-compact-diode-laser-based-photoacoustic/10.1117/1.JBO.29.1.017002.full#_=_
