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Medigene Presents Favorable Safety Profile of TCR-T Cells with Costimulatory Switch Protein at AACR Annual Meeting 2024

Planegg/Martinsried, April 8, 2024. Medigene AG (Medigene or the “Company”, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, today presents superior recombinant T cell receptor (rTCR) engineered T cell functionality as well as a favorable safety profile when rTCR-T cells are armored and enhanced with the PD1-41BB costimulatory switch protein (CSP) at the American Association for Cancer Research (AACR) Annual Meeting 2024 taking place April 5-10, 2024, in San Diego, USA. Medigene Presents Favorable Safety Profile of TCR-T Cells with Costimulatory Switch Protein at AACR Annual Meeting 2024

Researchers kill brain tumor cells with plasma

Scientists and physicians from the West Saxon University of Applied Sciences Zwickau (WHZ), the Heinrich Braun Hospital Zwickau (HBK), and the University Hospital Magdeburg have succeeded in killing brain tumor cells by treating them with physical plasma. The procedure is intended to make it possible to completely remove meningiomas. Brain tumors pose major challenges for both patients and treating physicians. Due to their displacing or invasive growth, they can cause significant neurological complaints and, in some cases, also threaten life. Unfortunately, the complete removal of a brain tumor is not always possible without endangering the patient's health. However, remaining tumor remnants increase the likelihood of renewed tumor growth. This is precisely where Prof. Dr. Maik Fröhlich from the West Saxon University of Applied Sciences Zwickau (WHZ) and physicians PD Dr. Michael Luchtmann and Dirar Aldabek from the Heinrich Braun Hospital Zwickau (HBK), as well as Prof. Dr. Christian Mawrin and Peter John from the Institute of Neuropathology at the University Hospital… 

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mRNA drug to lower blood lipids

According to a placebo-controlled, double-blind study led by researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, an experimental treatment may further lower blood triglycerides. The findings were presented at the American College of Cardiology 2024 Scientific Session & Expo and simultaneously published in the New England Journal of Medicine. In the study, 154 adults receiving lipid-lowering therapy with moderate-to-severe hypertriglyceridemia were randomized to receive either 50 mg of Olezarsen, 80 mg of Olezarsen, or placebo. Olezarsen is an antisense oligonucleotide that inhibits APOC3, a gene linked to higher triglyceride levels by targeting its mRNA. The subcutaneous drug was administered every four weeks for one year. Compared to placebo, Olezarsen lowered triglyceride levels by 49% at the 50-mg dose and by...

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Prostate cancer screening with PSA, Kallikrein Panel, and MRI

In this preliminary descriptive report from an ongoing randomized clinical trial, one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected among those randomized to be invited to undergo a single prostate cancer screening intervention compared with those not invited to undergo screening. These preliminary findings from a single round of screening should be interpreted cautiously, pending results of the study’s primary mortality outcome. Authors: Anssi Auvinen, M.D., Ph.D., of Tampere University in Tampere, Finland, is the corresponding author. https://jamanetwork.com/journals/jama/fullarticle/2817323?guestAccessKey=0ec76eb2-a05b-4ae3-b31c-7a662e979189&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040624

Oral vaccine for UTI is potential alternative to antibiotics

Recurrent Urinary Tract Infections (UTIs) can be prevented for up to nine years in more than half of people given an oral spray-based vaccine and is a potential alternative to antibiotic treatments, finds research. Initial results from the first long-term follow-up study of the safety and effectiveness of the MV140 vaccine for recurrent UTIs are presented this weekend at the European Association of Urology (EAU) Congress in Paris. They show that in both men and women with recurrent UTIs, 54% of study participants remained UTI-free for nine years after the vaccine, with no notable side effects reported. Full results of the study are expected to be published by the end of 2024.

EHRA 2024:  New evidence links passive smoking with dangerous heart rhythm disorder

Exposure to secondhand smoke – even at small amounts – is linked with greater risk of a serious heart rhythm disorder, according to research presented at EHRA 2024, a scientific congress of the European Society of Cardiology (ESC). The likelihood of atrial fibrillation increased as the duration of passive smoking lengthened. “The dangers of secondhand smoke were significant regardless of whether individuals were at home, outdoors, or at work, indicating that exposure universally elevates the risk of atrial fibrillation,” said study author Dr. Kyung-Yeon Lee of Seoul National University Hospital, Seoul, Republic of Korea. “We should all make every effort to avoid spending time in smoky environments. The findings should also drive policymakers to further curb smoking in public areas and support smoking cessation programmes to improve public health.” https://esc365.escardio.org/EHRA-Congress/sessions/10100

Experimental drug could further reduce lipids in the blood in high-risk patients

An experimental treatment could further lower triglycerides in the blood, according to a placebo-controlled and double-blind trial led by researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system. Results were presented at the 2024 American College of Cardiology’s Annual Scientific Session & Expo and simultaneously published in the New England Journal of Medicine. The trial randomized 154 adults on lipid-lowering therapy with moderate or severe hypertriglyceridemia to receive either 50mg olezarsen, 80mg olezarsen or placebo. Olezarsen is an antisense oligonucleotide that inhibits APOC3, a gene associated with higher levels of triglycerides, by targeting its mRNA. The subcutaneous medication was administered every four weeks, for a period of a year. Olezarsen reduced triglyceride levels by 49% at the 50mg dose and 53% at the 80mg dose, compared with placebo. The experimental drug also reduced… 

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Antengene Presents Four Preclinical Posters at AACR 2024

Antengene announced the presentation of four preclinical posters at the 2024 American Association for Cancer Research Annual Meeting (AACR 2024), taking place from April 5th to April 10th at the San Diego Convention Center in San Diego, California, the United States. The posters showcased four of Antengene’s high-potential emerging programs, including ATG-042, tracking to a H1 2025 IND filing; ATG-022, in Phase II dose expansion studies in China and Australia; AnTenGagerTM platform, Antengene’s proprietary T-cell engager (TCE) platform; and ATG-102, which could be the first IND candidate from AnTenGagerTM platform.

Antengene Presents Four Preclinical Posters at AACR 2024

Antengene announced the presentation of four preclinical posters at the 2024 American Association for Cancer Research Annual Meeting (AACR 2024), taking place from April 5th to April 10th at the San Diego Convention Center in San Diego, California, the United States. The posters showcased four of Antengene’s high-potential emerging programs, including ATG-042, tracking to a H1 2025 IND filing; ATG-022, in Phase II dose expansion studies in China and Australia; AnTenGagerTM platform, Antengene’s proprietary T-cell engager (TCE) platform; and ATG-102, which could be the first IND candidate from AnTenGagerTM platform.