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mRNA drug to lower blood lipids

According to a placebo-controlled, double-blind study led by researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, an experimental treatment may further lower blood triglycerides. The findings were presented at the American College of Cardiology 2024 Scientific Session & Expo and simultaneously published in the New England Journal of Medicine. In the study, 154 adults receiving lipid-lowering therapy with moderate-to-severe hypertriglyceridemia were randomized to receive either 50 mg of Olezarsen, 80 mg of Olezarsen, or placebo. Olezarsen is an antisense oligonucleotide that inhibits APOC3, a gene linked to higher triglyceride levels by targeting its mRNA. The subcutaneous drug was administered every four weeks for one year. Compared to placebo, Olezarsen lowered triglyceride levels by 49% at the 50-mg dose and by...

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Clarius and ThinkSono Introduce a New AI-Guided Ultrasound System Enabling Rapid Assessments of DVTs

Clarius Mobile Health, a leading provider of high-definition handheld ultrasound systems, and ThinkSono, a pioneering medical technology company specializing in ultrasound artificial intelligence (AI) guidance solutions, are introducing a new AI-guided ultrasound system in Europe, which will improve the efficiency of detecting deep vein thrombosis (DVT). ThinkSono Guidance, an AI App that pairs with Clarius ultrasound scanners, recently attained Class llb CE mark regulatory approval. DVT is a blood clot found commonly in the leg and is a leading cause of preventable hospital death in Europe and the United States. Patients often wait for hours or days for test results performed by ultrasound-trained clinicians.

Brain cancer community gets help in accessing clinical trials

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myTomorrows, a global health technology company connecting patients with all possible treatment options, today announced a new partnership with brainstrust, a UK-based charity that helps people living with a brain tumor reach their potential and thrive. Under the new partnership, people with brain tumors will be equipped with the means to bolster their knowledge of relevant treatment options, potentially extending to participation in clinical trials and access to pre-approval drugs. Moreover, the partnership provides a new layer of support to clinicians in their efforts to recruit patients to relevant clinical trials. There are 80,000 people living with a brain tumor in England alone, with a patient receiving a diagnosis every two hours. Brain tumors kill more children and adults under the age of 40 than any other cancer, and incidences and deaths from brain tumors are on the rise. With… 

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CREDIT: HIROSHI SHIIGI, OSAKA METROPOLITAN UNIVERSITY

Handheld sensor enables simultaneous detection of multiple bacteria

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When you hear the words E. coli or Salmonella, you immediately think of food poisoning. Rapid detection of such bacteria is crucial for preventing foodborne outbreaks. While it is common to bring food samples to a laboratory to determine the type and amount of bacteria that grow in a petri dish over a period of several days, a research team at Osaka Metropolitan University has developed a portable device for rapid on-site detection. Led by Professor Hiroshi Shiigi of the Graduate School of Engineering, the team experimented with a biosensor that can detect multiple pathogenic bacteria simultaneously within an hour. “The palm-sized detection device can be connected to a smartphone app to easily check the degree of bacterial contamination,” explained Professor Shiigi. His team synthesized organic-metal nanohybrids of gold and copper that mutually ...

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Bird flu jumps to humans

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China records the first human infection with the avian influenza virus A(H10N5). GENEVA, February 13. China has informed the World Health Organization (WHO) of a confirmed case of human infection with the avian influenza virus A(H10N5) in Anhui Province. This is the first globally reported case of human infection with this type of virus, reported the WHO office in Geneva. According to the agency, China's National Health Commission informed the WHO on January 27 about “a confirmed case of human co-infection with avian influenza virus A(H10N5) and seasonal influenza virus A(H3N2).” “This is the first globally reported case of human infection with avian influenza virus A(H10N5),” the agency said. The case occurred in a farmer over 60 years old from Xuancheng Prefecture in Anhui Province. Symptoms appeared on November 30, 2023, and she died on December 16, 2023. It is known that the patient ...

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