NAD+ and Zombie Cells: New Hope in the Fight Against Premature Aging
Oslo, July 3, 2025 – A groundbreaking study from the University of Oslo, published in Aging-US, shows that the molecule NAD+ plays a key role in the aging process and could serve as a potential treatment for Werner syndrome, a rare disease with accelerated aging. The research also opens up perspectives for understanding normal aging. "Werner syndrome causes affected individuals to age faster. By their 20s and 30s, they develop gray hair, wrinkles, and age-related diseases," explains Dr. Sofie Lautrup, a postdoctoral researcher at the University of Oslo. The study shows for the first time that patients with Werner syndrome have lower NAD+ levels in their mitochondria, which impairs cell function. "A lack of NAD+ disrupts energy production and DNA repair in cells," says Lautrup. Experiments revealed that supplying NAD+ can restore cell function. "We found that NAD+ stimulates stem cell growth and reverses premature aging in skin and stem cells…

