Brain tumor organoids precisely model patient response to CAR T-cell therapy

For the first time, researchers used lab-grown organoids derived from tumors of patients with glioblastoma (GBM) to accurately model a patient’s response to CAR T-cell therapy in real time. The organoid’s response to the therapy mirrored the response of the actual tumor in the patient’s brain.

Meaning, if the organoid derived from the tumor shrank after treatment, so did the patient’s actual tumor, according to new research from the Perelman School of Medicine at the University of Pennsylvania, published today in Cell Stem Cell.

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