Mechanisms of prostate tumor formation discovered
Researchers at the Free University of Brussels (ULB) have discovered the cellular reprogramming that leads to the development of prostate cancer. Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death worldwide in men. However, the mechanisms that control the early stages of prostate cancer development are not yet well understood. In a study published in the renowned journal Nature Cancer, researchers led by Professor Cédric Blanpain, MD/PhD, WELBIO researcher, head of the Laboratory of Stem Cells and Cancer and professor at the Free University of Brussels, discovered that inflammation caused by cancer-associated mutations leads to the reprogramming of mutated cells into cell states that are crucial for tumor formation. Chen Jiang and colleagues investigated the molecular mechanisms that regulate the early stages of prostate cancer development. They discovered that the cellular reprogramming events that lead to cancer development occur differently in different regions of the prostate. The ULB researchers discovered,…
