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IGF2BP1: A Crucial Driver of Cancer Progression and a Therapeutic Target

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death. As an m6A reader, IGF2BP1 binds to methylated mRNA, stabilizing oncogenic transcripts and promoting cancer progression. Its role in regulating gene expression at the post-transcriptional level has positioned IGF2BP1 as a potential biomarker for cancer prognosis and a target for novel anti-tumor therapies. Increased expression of IGF2BP1 has been observed in various cancers, including lung, liver, breast, and colorectal cancer, correlating with poor prognosis and therapeutic resistance. By interacting with m6A-modified mRNAs, IGF2BP1 enhances the stability and translation of cancer-driving genes, fueling tumor growth, invasion, and metabolic reprogramming. Its ability to promote immune evasion by stabilizing PD-L1 mRNA underscores its role in suppressing anti-tumor immunity. By influencing ferroptosis resistance, IGF2BP1 contributes to cancer cell survival under oxidative stress.… 

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Production of mesenchymal stem cells from iPS cells of dogs A method for producing MSCs opens up new possibilities in regenerative veterinary medicine

New method for producing stem cells revolutionizes canine medicine

A research team from Osaka Metropolitan University, led by Professor Shingo Hatoya and Dr. Masaya Tsukamoto, has developed a groundbreaking method for producing mesenchymal stem cells (MSCs) for veterinary medicine in dogs. MSCs, derived from fat or bone marrow, possess immunomodulatory and anti-inflammatory properties, but their proliferative capacity is limited, and their quality varies depending on donor age and collection site. The team generated induced pluripotent stem cells (iPSCs) from four different types of dog cells, which offer unlimited proliferative capacity and can be differentiated into various cell types. By applying a method established in human medicine, they succeeded in producing high-quality MSCs with high proliferative capacity and specific MSC markers. MSCs derived from urine cells were particularly effective. Dr. Tsukamoto emphasized that this method will advance regenerative veterinary medicine. Professor Hatoya announced that the immunoregulatory and therapeutic effects of iPSC-based MSCs will be further…

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Cannabis for everyone Credits LabNews Media LLC

DoktorABC revolutionizes cannabis therapy at Mary Jane Berlin 2025

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At Mary Jane Berlin 2025, DoktorABC, Germany's leading platform for digital healthcare, presents innovative solutions for quick and safe access to medical cannabis. The trade fair, taking place from June 19-22, will be a showcase for modern cannabis therapy, with DoktorABC at its center. The platform eliminates hurdles such as long waiting times and lack of transparency. By connecting with over 500 pharmacies, DoktorABC offers real-time data on availability and strains. Patients receive a digital prescription after an online medical consultation – discreet, compliant with the law, and medically supervised. In many regions, delivery occurs the same day, sometimes even within 60 minutes. The premium package includes personal consultation, choice of up to three strains, a free cannabis patient ID, prescription issuance, express or DHL delivery, and uncomplicated follow-up prescriptions. If no prescription is issued, there are no costs. In addition to cannabis therapy, DoktorABC covers over 40 medical areas, including sleep disorders, allergies, and 

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Medical technology starts 2025 with a slight upward trend

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The German medical technology sector is showing moderate growth at the beginning of 2025. According to the Federal Statistical Office, nominal sales in the first quarter increased by 3.4 percent compared to the previous year. After a subdued 2024, in which the more than 1,500 companies achieved total sales of 41.4 billion euros (+2.5%), the industry is holding its ground despite economic challenges. Domestic sales grew by 1.7 percent to 13.2 billion euros, and foreign business by 2.9 percent to 28.2 billion euros, with a stable export ratio of 68 percent. The number of employees rose by 2.8 percent to approximately 166,000. Dr. Martin Leonhard, Chairman of the SPECTARIS Medical Technology Association, has mixed feelings about the development. Pent-up investment in healthcare, high costs, and bureaucratic effort are burdening the industry, especially domestically. The financial situation of clinics is leading to postponed purchases of modern technologies. Furthermore, the European Medical Device Regulation and planned PFAS restrictions are complicating production, as supply chain problems loom. Despite challenges 

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Highly sensitive trace analysis is necessary for the detection of particularly toxic chemicals in environmental samples | Source Karin Hiller | Copyright RPTU

Hundreds of thousands of chemicals are harmful to the environment: measurement data is missing

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Scientists at the Rhineland-Palatinate Technical University of Kaiserslautern-Landau (RPTU) have demonstrated in a study published in the journal "Science" that for the vast majority of potentially environmentally harmful chemicals, no measurement data from water bodies are available. Of nearly 300,000 chemicals classified as environmentally relevant by the US Environmental Protection Agency (EPA), less than one percent have data from water monitoring. Furthermore, some substances act at concentrations that cannot be detected with standard methods, making risk assessment difficult. The researchers analyzed an extensive US database with over 64 million measurements from 1958 to 2019 for around 1,900 chemicals. In the 1970s, heavy metals such as copper or lead frequently exceeded the toxicity thresholds for aquatic organisms. Due to discharge controls, their concentration decreased. Since the 2000s, exceedances have spread to more organic chemicals like pharmaceuticals or pesticides, but many measurements have been discontinued, limiting risk assessment. Particularly problematic are… 

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International Law and the Bombing of Hospitals: Gaza, Iran-Israel Conflict, and the Legal Framework

The bombing of hospitals in armed conflicts raises complex international law questions, as these facilities enjoy special protection. International humanitarian law, particularly the Geneva Conventions, sets clear rules to protect civilians and medical infrastructure in times of war. Nevertheless, in conflicts such as in the Gaza Strip or the recent Iran-Israel conflict in 2025, attacks on hospitals repeatedly occur, triggering both legal and ethical debates. This article examines the principles of international law, analyzes the situation in Gaza and the Iranian attack on a hospital in Israel, and discusses the challenges in enforcing international law. International Law and the Protection of Hospitals International humanitarian law, a central component of international law, governs the conduct of states and non-state actors in armed conflicts. The four Geneva Conventions of 1949 and their Additional Protocols of 1977 form the basis for the protection of civilians,… 

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World first: Intelligent sensor detects breathing via the wrist

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Researchers from the North University of China and Xiamen University have introduced a novel wearable system that reads breathing patterns directly from pulse signals at the wrist. The study, published on May 16, 2025, in Microsystems & Nanoengineering (DOI: 10.1038/s41378-025-00924-4), describes a miniaturized, AI-powered device that integrates a flexible pressure sensor with a deep neural network. The sensor system enables continuous respiratory monitoring with high comfort and clinical precision, offering a promising alternative to conventional respiratory monitors. At the heart of the system is a 300 ?m thick flexible pressure sensor inspired by the structure of a human fingertip. The sensor, printed on thermoplastic polyurethane (TPU), can detect subtle fluctuations in pulse waves caused by breathing. These signals—categorized as respiration-induced amplitude variation (RIAV), respiration-induced fluctuation of ventricular filling (RIFV), and respiration-induced variation of the baseline value (RIIV)—are transmitted via Bluetooth to a mobile application and processed using a hybrid neural network…

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Self-Esteem Increases Within a Year After Weight-Loss Surgery

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WASHINGTON, DC – June 19, 2025 – Self-esteem more than doubled within a year after weight-loss surgery, according to a new study presented today at the 2025 American Society for Metabolic and Bariatric Surgery (ASMBS) Annual Meeting. Researchers from Geisinger Medical Center found that self-esteem increased from 33.6 to 77.5 after bariatric surgery – an increase of more than 40 points. Higher scores on a scale of 0 to 100 indicate higher self-esteem and quality of life. The amount of weight lost appears to drive the increase in self-esteem – those who lost the most weight achieved the highest scores, despite demographic differences such as sex, age, ethnicity, or type of bariatric procedure. Researchers used a prospectively maintained database to examine 5,749 patients aged 18 and older with a body mass index (BMI)… 

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Living Near Ocean Polluted by Microplastics Increases Heart Attack Risk

Living in a U.S. coastal county bordering seawater with very high concentrations of microplastics may increase the risk of heart and metabolic diseases such as type 2 diabetes, coronary heart disease, and stroke. This risk was higher compared to residents of coastal counties with low microplastic exposure from surrounding waters. This is according to a new study published today in the Journal of the American Heart Association, a free open-access, peer-reviewed scholarly journal of the American Heart Association. "This is one of the first large-scale studies to suggest that living near waters heavily polluted with microplastics may be linked to chronic diseases. Plastic pollution is not only an environmental problem, but it can also be a public health risk," said Dr. Sarju Ganatra, lead author of the study, medical director of sustainability, vice chair of the medical department at Lahey Hospital & Medical Center... 

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Trump zwischen Friedensnobelpreis und Untergang Credits LabNews Media LLC

Trump between Nobel Peace Prize and Downfall

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The Middle East is burning again. The escalating conflict between Israel and Iran threatens to plunge the region into chaos that could overshadow even the worst days of recent history. Amidst this geopolitical powder keg, U.S. President Donald Trump faces a decision that will decisively shape not only the future of the Middle East but also his own political legacy and that of his "Make America Great Again" (MAGA) movement. The choice is clear: either he intervenes militarily, risking a new Afghanistan-like nightmare that could drag MAGA and his presidency into the abyss, or he opts for bold diplomacy, brokers peace between Israel and Iran, and secures a place in the history books – perhaps even with the Nobel Peace Prize. The parallels to historical precedents such as the Afghanistan disaster and the Camp David Accords under Jimmy Carter are striking and serve as a cautionary tale... 

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