Epigenetic drugs could protect blood vessels in obesity and diabetes
Zürich (LabNews Media LLC) – Epigenetic active agents could help prevent vascular damage in people with obesity and type 2 diabetes in the future. This is shown by a study by researchers at the University of Zurich (UZH) and University Hospital Zurich, led by cardiologist Francesco Paneni. The focus is on perivascular adipose tissue, which surrounds blood vessels and regulates their relaxation and the inflammatory response of the vascular inner wall through chemical signals. In obesity and metabolic diseases, this adipose tissue becomes inflamed, accumulates more lipids, and releases substances that stiffen the vessels and make them less responsive. This contributes to the development of early vascular diseases and increases the risk of heart attacks and strokes. The researchers used so-called BET protein inhibitors, which influence epigenetic regulators and thereby reprogram gene activity in perivascular adipose tissue. In experiments on mice and human tissue, the treatment led to a significant reduction in inflammatory processes. The vessels relaxed better, and…




