Skip to content

New Insights into Non-Inflammatory Causes of Rare Neurological Symptoms in Children

View in Browser Get Custom Content for Your Website or Blog Enhance your website’s or blog’s content with PR Newswire’s customized real-time news feeds. Whether you have a general information portal, or a blog dedicated to a niche audience, we can build a news feed to match your content needs. You can provide your visitors with fresh news targeted to their interests distributed directly from a trusted news source. Learn more News From Children’s Hospital of PhiladelphiaTransmitted by PR Newswire for Journalists on September 26, 2024 11:10 AM EDT Researchers at Children’s Hospital of Philadelphia Reveal New Insights into Non-Inflammatory Causes of Rare Neurological Symptoms in Children, Adolescents and Young Adults Following CAR-T Therapy Study marks the first time these side effects were reported in children PHILADELPHIA, Sept. 26, 2024 /PRNewswire/ — Researchers at Children’s Hospital of Philadelphia (CHOP) revealed… 

more »New Insights into Non-Inflammatory Causes of Rare Neurological Symptoms in Children

American Lung Association Campaign Aims to Address Lack of Diversity in Clinical Trials

In the past decade, clinical trials have contributed to rapidly advancing research, which has led to more individuals living with lung cancer exceeding the five-year survival rate than ever before. Unfortunately, this progress has not been shared equally amongst the populations facing high lung cancer burdens. That’s why the American Lung Association is expanding its work through the Awareness, Trust and Action program to educate Hispanic individuals about clinical trials and encourage them to speak with their healthcare provider about their treatment options. While progress in the early detection and treatment of the disease in recent years has increased the five-year survival rate to 26.6% nationally, this progress has not been shared equally. Hispanic individuals with lung cancer were 16% less likely to be diagnosed early, 30% more likely to not receive any treatment, and 9% less likely to survive… 

more »American Lung Association Campaign Aims to Address Lack of Diversity in Clinical Trials

Kyowa Kirin: Top-line Data from Rocatinlimab Phase 3 trial

Kyowa Kirin Co., Ltd. (Kyowa Kirin) (TSE:4151) (President and CEO: Masashi Miyamoto) announced top-line results of the Phase 3 ROCKET HORIZON trial of rocatinlimab, an investigational therapy targeting the OX40 receptor. HORIZON met its co-primary endpoints: achievement of a validated Investigator Global Assessment for Atopic Dermatitis (vIGA-ADTM) score of 0 (clear) or 1 (almost clear) with a ? 2-point reduction from baseline [19.3% rocatinlimab vs. 6.6% placebo (12.8% difference, p<0.001)] and achievement of ? 75% reduction from baseline in Eczema Area and Severity Index score (EASI-75) [32.8% rocatinlimab vs. 13.7% placebo (19.1% difference, p<0.001)], both at week 24. The trial also met the revised Investigator Global Assessment (rIGA 0/1) *[1], a more stringent measure of efficacy than vIGA 0/1 based on a narrower definition of 1 (almost clear), at week 24 [16.4% rocatinlimab vs. 4.9% placebo (11.5% difference, p<0.001)]. HORIZON… 

more »Kyowa Kirin: Top-line Data from Rocatinlimab Phase 3 trial

Campylobacter jejuni-specific antibody offers hope for vaccine development

  • News

Bacterial infections leading to enteritis, sometimes extraintestinal infections such as sepsis, remain a global health problem. One of the main causes of death from diarrheal diseases and extraintestinal infections in children under 5 years old and the elderly is infection with Campylobacter bacteria, for which there is neither an effective vaccine nor drugs. A team led by Osaka Metropolitan University recently discovered something that could be an important step toward the prevention, diagnosis, and treatment of a type of Campylobacter bacteria. Researchers, including Professor Shinji Yamasaki and Associate Professor Noritoshi Hatanaka from the Graduate School of Veterinary Science and the Osaka International Research Center for Infectious Diseases at OMU, focused on Campylobacter jejuni, the bacterial species that commonly causes gastroenteritis and sometimes extraintestinal infections. Together, they developed an antibody that can identify C. jejuni and inhibit the growth of the bacteria.… 

more »Campylobacter jejuni-specific antibody offers hope for vaccine development

Study: Good sex through good self-esteem

A long-term study by the Universities of Zurich and Utrecht has confirmed a dynamic interaction between self-esteem and sexual satisfaction. The results provide impetus for measures to improve sexual well-being. Various theories assume that people with higher self-esteem generally also have more satisfying sexual relationships and that the two mutually influence each other. However, little has been investigated so far about how this interaction develops over time. A new study, based on a nationally representative sample of over 11,000 German adults, provides interesting insights into this. In this study, researchers from the Universities of Zurich (UZH) and Utrecht analyzed data collected over a period of 12 years. "People with higher self-esteem tend not only to be more sexually active but also to experience greater satisfaction with their sexual experiences," explain the authors Elisa Weber and… 

more »Study: Good Sex Through Good Self-Esteem

Lyme disease: Symptoms and lab values

Lyme disease is a bacterial infectious disease transmitted by ticks that can affect various organ systems. The disease typically progresses in several stages with different symptoms. Early diagnosis and treatment are important to avoid complications. Symptoms The symptoms of Lyme disease can be diverse and often appear in different stages: Early stage (Stage I) Erythema migrans: A ring-shaped, spreading redness of the skin around the bite site, which occurs in about 90% of those affected Flu-like symptoms such as fever, muscle and joint pain, fatigue Swollen lymph nodes Extended early stage (Stage II) Multiple skin rashes (polytope erythema) Joint inflammation (arthritis) Nerve inflammation (neuritis) with possible paralysis, especially facial paralysis Heart problems such as heart rhythm disturbances (rare) Late stage (Stage III) Chronic joint inflammation, especially of the knee joints Chronic skin inflammation (Acrodermatitis chronica atrophicans) Persistent neurological symptoms such as numbness, visual or hearing disturbances Lab values and diagnostics The diagnosis of Lyme disease is based on a combination of clinical symptoms, medical history, and laboratory tests: Antibody tests IgM antibodies: Are detected in the early stages of infection… 

more »Lyme disease: Symptoms and lab values

Failure of laboratory medicine would trigger revolts

The consequences of a failure of laboratory medicine in Germany would be devastating: The political stability of the Federal Republic would be shaken. This is the conclusion of an AI analysis commissioned by LabNews. Immediate consequences (1-3 days) Emergency care – Emergency rooms would be severely affected, as important blood tests for the diagnosis of heart attacks, strokes, or poisonings would be missing. – The treatment of intensive care patients would be complicated, as regular blood gas analyses and electrolyte determinations would not be possible. Chronic diseases – Patients with diabetes could no longer monitor their blood sugar levels, which could lead to dangerous imbalances. – The adjustment of medications for cardiovascular diseases or thyroid disorders would no longer be possible. Medium-term consequences (4-14 days) Infectious diseases – The diagnosis and treatment of infectious diseases would be severely hampered, as pathogen determinations would no longer be possible. – The monitoring of antibiotic resistance would cease, which could lead to an increase in difficult-to-treat infections. Cancer treatment – Important tumor markers could not be…

more »Failure of laboratory medicine would trigger revolts

Take Off: German Congress for Laboratory Medicine (DKLM 2024)

The pace and extent of globalization are constantly increasing: thanks to technological progress, transport costs have fallen significantly, international goods traffic and trade have increased considerably, and production processes and the division of labor have become internationalized. At the same time, people all over the world are leaving their ancestral homes, seeking protection from war, persecution, fleeing from social or medical emergencies. However, goods traffic and migration present challenges that medicine, and laboratory medicine in particular, must face. In particular, doctors may be confronted with diseases that have not occurred in Europe for decades, or new pathogens may emerge. Language barriers, cultural differences, and different perceptions of illness complicate treatment, but a lack of practical knowledge also plays a role. Laboratory medicine can make a crucial contribution to the understanding, detection, and analysis of diseases, thus providing the treating physician with an important tool for therapy. Also… 

more »Take Off: German Congress for Laboratory Medicine (DKLM 2024)

Abuse of power at German universities

  • News

On October 8 and 9, 2024, a nationwide conference on the topic of abuse of power at universities will take place at the Technical University of Berlin under the name "Our UNIverse: Empowered to speak up". The aim of the conference is not only to raise awareness of the topic but also to analyze the current situation at universities. The conference program can be accessed here (https://www.tu.berlin/go266200/). Some highlights include:• Keynote: Abuse of power in science with Prof. Dr. Jutta Stahl, Professor of Differential Psychology and Psychological Diagnostics, University of Cologne• Keynote: Political levers in the fight against abuse of power with Carolin Wagner, SPD Member of the Bundestag• Panel discussion: How can the wall of silence be broken?• Workshops & Lectures: Understanding abuse of power, best practices, developing measures against abuse of power.

Glioblastoma: Analysis tool quantifies plasticity of tumor cells

  • News

A new, powerful analysis tool provides a more accurate insight into how tumor cells change their shape, becoming more aggressive and untreatable. This is shown by a study by researchers at Weill Cornell Medicine and the  New York Genome Center . A tumor cell changes its shape by altering its cell type or state, thereby changing its fundamental pattern of activity and possibly even its appearance. This variability, or "plasticity," is a hallmark of cancer that leads to diverse tumor cell populations and ultimately to the emergence of cell types that enable treatment resistance and metastasis. The new tool, described in a  paper  in Nature Genetics on September 24, allows this plasticity to be quantified in tumor cell samples. The researchers demonstrated this using analyses of tumor samples from animal models and human patients, identifying, for example, a critical transitional cell state in glioblastoma, the most common form… 

more »Glioblastoma: Analysis tool quantifies tumor cell plasticity