رؤى جديدة حول تجديد الكبد بعد العمليات الجراحية
Researchers at Michigan State University have refuted a long-standing scientific consensus on the role of the protein plasminogen in liver regeneration after surgery. Lower plasminogen levels promoted cell regeneration in mouse experiments. The findings influenced a clinical trial in which the administration of tranexamic acid (TXA) reduced the risk of liver failure. The results were published in the journal Blood. Plasminogen hinders rather than promotes regeneration James Luyendyk and his team at Michigan State University originally investigated the role of plasminogen, a protein involved in breaking down blood clots. Previous studies had suggested a positive effect on liver regeneration. However, the experiments showed the opposite: with reduced plasminogen levels, the liver regenerated more strongly. The findings led to a clinical investigation in the HeLiX study. Background The liver is one of the few organs that can regenerate after partial removal (hepatectomy). However, postoperative liver failure remains a serious complication. Tranexamic acid (TXA) is commonly used to reduce bleeding…
