The Lung Cancer Research Foundation (LCRF) is pleased to announce its partnership with Israel Cancer Research Fund (ICRF) on a project led by Joel Yisraeli, PhD, and his lab in the Department of Developmental Biology and Cancer Research at the Hebrew University of Jerusalem. The ICRF-LCRF Project Grant is a three-year, $180,000 award.
The project, titled „Treating Lung and Colorectal Carcinomas by Targeting IGFBP1“ will study the effects of an IGF2BP1 inhibitor discovered by Professor Yisraeli and his team, building upon previous ICRF-funded research.
IGF2BP1 is a protein that binds to RNA and is usually active before birth, but it becomes active again in many types of cancers. In patients with lung adenocarcinoma, those with high levels of IGF2BP1 and a mutated KRAS gene have a much lower survival rate (15 months) compared to those without high levels of IGF2BP1 (88 months). In mice, when IGF2BP1 is active along with the mutant KRAS gene, it helps tumors grow in the lungs and spread to other parts of the body. However, blocking IGF2BP1 can prevent these tumors from spreading.
