Saliva activates coagulation in persons with haemophilia A
A recent study led by MedUni Vienna provides new insights into the mechanisms of coagulation in persons with haemophilia A, the most common form of haemophilia. The research team was able to show that saliva contains special vesicles that trigger rapid coagulation of the blood of haemophilic patients. The results, which were recently published in the renowned scientific journal „Blood“, contribute significantly to a better understanding of the disease. Haemophilia is a hereditary blood disorder characterised by a deficiency of certain coagulation factors, which can lead to life-threatening bleeding if left untreated. Why haemophilia A (with factor VIII deficiency) often leads to joint bleeding, but rarely to mucosal bleeding, was previously unclear. In search of an explanation, the scientific team led by Johannes Thaler and Cihan Ay (Clinical Division of Hematology and Hemostaseology, Department of Medicine I, MedUni Vienna) and…
